Enhanced Synthesis Of Silica-coated Ferrimagnetic Nanoparticles For Biomedical Use
ID U-5820
Category Chemicals
Subcategory Nanochemicals
Researchers
Brief Summary
A novel synthesis method for discrete, silica-coated ferrimagnetic nanoparticles with high saturation magnetization and colloidal stability has been developed, suitable for targeted biomedical applications.
Problem Statement
The challenge in nanoparticle synthesis is preventing the agglomeration of seed particles due to strong magnetic interactions, which is crucial for maintaining discrete nanoparticles during the coating process
Technology Description
The described technology provides an innovative approach to synthesizing discrete silica-coated ferrimagnetic nanoparticles. By employing a layer-by-layer deposition of polyelectrolytes around zinc ferrite nanocubes, the method prevents the typical agglomeration caused by magnetic interactions. This process not only maintains the discrete nature of the nanoparticles but also enhances their colloidal stability and functionality. The silica coating serves multiple purposes: it protects the magnetic core, allows for the attachment of various biological molecules, and improves the nanoparticles’ overall stability, making them highly suitable for biomedical applications such as targeted drug delivery and diagnostic imaging.
Stage of Development
Proof of Concept
Benefit
- High Magnetic Saturation: Ensures a strong response to magnetic fields, ideal for precise control in medical applications.
- Colloidal Stability: Reduces the risk of aggregation, maintaining the nanoparticles’ effectiveness in biological environments.
- Versatile Functionalization: The silica shell facilitates the attachment of biological entities, enabling targeted therapies.
- Biomedical Application Potential: The nanoparticles are designed for use in MRI contrast enhancement, bioseparation, and targeted drug delivery systems.
Publications
Park J, Porter MD, Granger MC. Silica encapsulation of ferrimagnetic zinc ferrite nanocubes enabled by layer-by-layer polyelectrolyte deposition. Langmuir. 2015;31(11):3537-3545. doi:10.1021/acs.langmuir.5b00268
Park J, Porter MD, Granger MC. Colloidally Assembled Zinc Ferrite Magnetic Beads: Superparamagnetic Labels with High Magnetic Moments for MR Sensors. ACS Appl Mater Interfaces. 2017;9(23):19569-19577. doi:10.1021/acsami.7b03182
IP
Publication Number: 2016-0211062
Patent Title: Discrete Magnetic Nanoparticles
Jurisdiction/Country: United States
Application Type: Non-Provisional
Contact Info
Dean Gallagher
(801) 585-0396
dean.gallagher@utah.edu
