Advanced Selp Embolic Solutions For Vascular Interventions

A novel silk-elastinlike protein polymer (SELP) has been developed as a thermally responsive hydrogel for creating safer, more effective embolic plugs in vascular treatments.

Current embolic materials for treating vascular malformations and aneurysms often involve toxic byproducts and lack biodegradability, posing risks to patients and limiting treatment efficacy.

SELP represents a breakthrough in embolic technology, combining the durability of silkworm silk with the flexibility of mammalian elastin. This biocompatible and biodegradable hydrogel transitions from liquid to solid at body temperature, allowing for minimally invasive delivery through a microcatheter. Upon injection, SELP forms a solid embolic plug that reinforces weakened vasculature, such as in aneurysms, and reduces blood flow in arteriovenous malformations, enhancing surgical outcomes and reducing hemorrhage risks.

Pre-Clinical Validation

• Biocompatibility: SELP is highly compatible with human tissue, reducing the risk of adverse reactions.
• Biodegradability: Unlike current options, SELP degrades naturally over time, minimizing long-term complications.
• Optimal Filling: The liquid nature of SELP allows for complete filling of aneurysmal sacs, significantly reducing the chance of recanalization.
• Cost-Effective Production: Despite higher initial production costs, SELP’s potential market price offers significant room for profit while providing a safer alternative to patients.

Jensen MM, Hatlevik Ø, Steinhauff DD, et al. Protein-based polymer liquid embolics for cerebral aneurysms. Acta Biomater. 2022;151:174-182. doi:10.1016/j.actbio.2022.08.003

Steven Christiansen
801.587.0915
steven.christiansen@utah.edu