Dielectrophoretic Assessment Of Critical Quality Attributes Of Nanoparticles

ID U-7980

Category Biotechnology

Subcategory

Brief Summary

This technology offers a breakthrough method for rapidly screening and characterizing nanoparticles, including extracellular vesicles, based on their electrophysical properties.

Problem Statement

The traditional methods for nanoparticle characterization are time-consuming and costly, lacking rapid screening for quality assurance and non-destructive isolation techniques, which poses challenges in real-time process feedback during manufacturing.

Technology Description

The technology utilizes dielectrophoresis (DEP) to assess the Critical Quality Attributes (CQAs) of nanoparticles by creating and analyzing static and dynamic retention patterns. This label-free method, characterized by light scattering, enables the rapid, non-destructive isolation, concentration, and detection of nanoparticles, providing a comprehensive profile of their size, zeta potential, and concentration in a sample. Quality control, supply chain assurance, real-time manufacturing oversight, product branding, and the development of therapeutic vesicles are key aspects in advancing the field of nanoparticle technology for regenerative medicine.

Benefit

  • Rapid and label-free characterization of nanoparticles.
  • Ability to distinguish nanoparticles based on size, concentration, and zeta potential.
  • Facilitates the rapid screening of nanoparticles for consistency and quality assurance.
  • Offers real-time feedback for the adjustment of manufacturing processes to maintain or achieve desired CQA.
  • Enables the non-destructive isolation and concentration of nanoparticles, preserving their integrity for further analysis.
  • Utilizes existing technology (U-6750) for novel applications in nanoparticle characterization.


Contact Info

Jonathan Tyler
801-587-0515
jonathan.tyler@utah.edu

Questions?

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