This invention identifies gene expression patterns that predict the regenerative capacity of donor cells for cartilage repair, enhancing the efficacy of cell-based therapies.

There is a lack of reliable molecular or genetic identifiers to screen donor cell sources for their ability to regenerate cartilage effectively in vivo.

The technology leverages specific gene expression patterns in donor cells to predict their in vivo cartilage regenerative capacity. It utilizes molecular and genetic profiles that consistently exhibit stable therapeutic qualities, high-quality hyaline cartilage formation, and subchondral bone regeneration. This approach marks a significant advancement over current methods by providing a reliable screening process for selecting donor cells with robust regenerative capabilities, which is crucial for improving the quality of cell-based joint cartilage regeneration procedures.

Optimization & Testing

• Reliable Screening: Offers a dependable method to predict the regenerative potential of donor cells for cartilage therapies.
• Enhanced Cartilage Repair: Improves the quality of cell-based joint cartilage regeneration for replacement and repair procedures.
• Predictive In Vivo Performance: Enables the prediction of therapeutic cartilage implants’ performance in vivo.
• Comprehensive Marker Expression: Utilizes a combination of hyaline cartilage and bone-forming markers for a thorough regeneration assessment.

https://www.cstecutah.com/

Huy Tran
(801) 581-7792
huy.tran@utah.edu