Slide
By the Numbers

The University of Utah ranks among the top-10 public universities for issued patents and revenue generation.

Numbers from fiscal year 2025 (July 1, 2024-June 30, 2025).

Licensing Revenue icon
$0.4m
Licensing Revenue
Licenses icon
0
Licenses
U.S. Patents Issued icon
0
U.S. Patents
Issued
Startups icon
0
Startups
Invention Disclosures icon
0
Invention
Disclosures
Patents  Filed icon
0
Patents
Filed

Featured News

As aggressive brain and spine cancers pose serious threats to patients’ lives, researchers are hastening efforts to find effective and reliable a

Trace AQ, a U of U startup, has created Flow AQ, incorporating their cutting-edge, physics-based forecasting model into an accessible, easy-to-us

When single-use electronics are discarded, they often end up in U.S. landfills or are exported overseas for processing. EnduraCure, a University

View All News

Patient getting brain scan

Calycia LogoAs aggressive brain and spine cancers pose serious threats to patients’ lives, researchers are hastening efforts to find effective and reliable alternative treatments to radiation and chemotherapy. University of Utah startup CaLycia Bioscience is working to engineer immune cells from a patient’s body to fight and kill cancer cells, effectively treating the cancer from within.

A Deadly Threat to Patients’ Lives

Diagram of glioblastoma within brainThe Mayo Clinic describes glioblastoma multiforme as an aggressive, rapidly growing form of brain cancer that starts as a growth of cells in the brain or spinal cord. Tumors grow and infiltrate the brain with fingerlike tendrils, making complete surgical removal virtually impossible. Patients diagnosed with glioblastoma suffer from headaches, nausea, memory loss, balance issues, vision changes, speech difficulties, and seizures. This particular form of cancer, according to the American Brain Tumor Association, has devastating survival rates. The 5-year survival rate for patients diagnosed with glioblastoma is under 30% for adolescents and adults under 40, and under 6% for adults over the age of 40, making the search for new and effective treatments all the more urgent.

A New and Novel Treatment

Currently, glioblastoma is treated with surgical removal of the tumor, followed by radiation and chemotherapy. Because complete removal of the tumor is difficult, however, there are always residual cells left behind that tend to regrow the tumor. In the past, immune cells called T-cells have been engineered with chimeric antigen receptors (CAR), which enable the new CAR-T cells to identify and kill cancer cells when they are returned to the patient. And while these cells work well in fighting blood cancers, they are incompatible with solid tumors like glioblastoma. Illustration of macrophageResearchers here at the U are innovating to apply this principle to a different kind of immune cell, the macrophage. These cells are ideal candidates for engineering because they can travel into solid tumors, traffic all over the body, and eat and kill their targets. “Macrophages play a really interesting role in the immune system where they can educate the rest of the immune system,” CaLycia Bioscience co-founder Minna Roh-Johnson explained, “There’s this ripple effect of direct eating, educating the other immune cells. Macrophages can get into the tumor, and we think that will prove to be very advantageous.” Ideally, these macrophages will be taken from a cancer patient via blood draw, engineered to target the residual glioblastoma cells post-surgery, destroying them and teaching the rest of the immune cells to follow suit.  

The Bridge from University to Business

The team at CaLycia Bioscience has been researching macrophage engineering for years now. It started in Associate Professor of Biochemistry Minna Roh-Johnson’s lab, where she began working with Daniel Greiner, now the president of CaLycia Bioscience, on his PhD. Their research continued through Greiner’s PhD, which finished last year, and while they were both excited and passionate about their research, they didn’t know if they had the resources to support a continued study. The co-founders were left at a crossroads: they could move on to different projects, or they could take their research out of the lab and into a commercial space. “We were kind of in a tough spot,” Roh-Johnson shared, “which I think a lot of people are, where you need to get the sort of money to be able to do the experiments, but you’re not ready for prime-time normal sources of funding.” The team made the decision to continue their work, but they were cautious about making the transition from academia to business. Greiner explained, “There’s a million ways startups fail, and most of them don’t actually involve the science.” With their concerns and questions in mind, the co-founders turned to the university for support.

Engagement with University Resources

Image from Doman Innovation Studio CohortCaLycia Bioscience’s first step in seeking funding was applying for the Ascender Grant, a university grant meant to bridge the gap between academic research and commercialization. This grant allowed them to reach several important milestones in their research, paving the way to receive more funding. Then the team applied for the Launchpad Seed Fund, developed by the Utah Venture Hub to support early business development work. This funding allowed Roh-Johnson and Greiner to continue their work and further support their company. One form of that support came through the Doman Innovation Studio in the David Eccles School of Business. In starting a business, Greiner mentioned that “you don’t know what you don’t know,” and that the Doman Innovation Studio proved to be of immense help, providing advice, counselling, and resources to help the co-founders navigate the ins and outs of translating their research to a business setting. “CaLycia Bioscience is a prime example of a startup taking advantages of the resources the university has cultivated for this purpose,” Jim Hotaling, AVPR for Research & Translation, shared, “It’s amazing to see a company go through the full pipeline of funding we have here to translate their academic research into a high-potential business.”

Recent Funding

CaLycia Bioscience closed their most recent funding round led by University of Utah Ventures and Cumming Capital Management, successfully utilizing the hub for cross-campus collaboration and participating in the ecosystem of entrepreneurship fostered by the university. This next round of funding will allow the team to expand, hire additional technicians, and begin preclinical experiments, working toward their novel, innovative treatment for this aggressive and deadly form of brain cancer.

"CaLycia is a standout example of the University of Utah’s world-class scientific talent translating breakthrough research into life-saving therapies. University of Utah Ventures' investment in Calycia reflects our commitment to supporting high-impact, innovative technologies led by exceptional teams". - Jack Boren, Managing Partner, University of Utah Ventures

“The Cumming Foundation is pleased to announce its investment in CaLycia Bioscience to support the company’s groundbreaking macrophage research aimed at developing innovative cancer treatments. The foundation is inspired by CaLycia’s scientific vision, confident in the dedication of its research team, and hopeful that this partnership will contribute meaningfully to the fight against cancer.” -Matt Ireland, Managing Director, Cumming Capital Management  

 

Learn More about Calycia Bioscience

Learn more about University of Utah Ventures

Flow AQ 2Trace AQ, a U of U startup, has created Flow AQ, incorporating their cutting-edge, physics-based forecasting model into an accessible, easy-to-use mobile app that allows users to adapt to the impacts of changing and potentially hazardous air conditions.

A Critical Issue in Salt Lake City & Beyond

Every day, residents of Salt Lake City may breathe in air affected by wildfire smoke, inversion, dust, ozone, and other air pollution, impacting each individual’s respiratory system and making poor air quality one of the most prominent health concerns in the area.

According to research, exposure to the many factors impacting Salt Lake City's air can have negative impacts on respiratory health, including shortness of breath, difficulty breathing, chest pain, wheezing, coughing, and fatigue. Prolonged exposure to dusty air, smoky air, polluted air, or ozone can worsen preexisting cardiovascular/heart diseases, asthma, and chronic bronchitis. However, for the critical problem poor air quality presents, it isn’t monitored as closely as many other parts of a weather forecast, making it difficult for athletes or others who train or recreate outside to avoid breathing in harmful air.

Using Flow AQ to Avoid Hazardous Air

Feature 1Trace AQ, a data science-driven smoke and air quality forecasting technology company, recently released Flow AQ, an app providing forecasts, real-time conditions, personalized alerts, and health-driven insights into local air quality. Flow AQ’s forecasts differ from many other forecast services in that they incorporate physics-based solutions, where most forecasts in the commercial space limit their models to machine-based learning solutions derived from sensor data. This allows Trace AQ to produce a longer and more accurate forecast (96 hours) than ever before, which encourages users to be proactive and plan for poor air quality, rather than reacting once poor air quality is already here. This is especially useful for athletes of all ages with strict training and practice schedules.

The CTO of the startup, Taylor (Kai) Wilmot, shared, “A tool like this could be valuable as far as helping plan your training routine or, you know, helping you avoid the most degraded air quality, like things that will have significant impacts on your respiratory system.”

Because several Trace AQ team members have extensive experience in wildfire smoke research, their forecast has a unique ability to forecast smoke’s impact on air quality, but using a variety of techniques, their system is being built to address all factors in air quality.

Wilmot went on to share, “Our forecasts have correctly predicted upwards of 400% more unhealthy air quality events than our competitors or publicly available forecasts throughout the 2025 fire season.”

With the accurate and personalized air quality forecasts and alerts on Trace AQ’s app, users can be proactive instead of reactive to air quality and adjust their outdoor lifestyles to avoid hazardous air conditions.

Starting a Company Based on Use-Inspired Research

The research behind Trace AQ began as a National Science Foundation (NSF) project that was funded through the University of Utah’s Chemical Engineering Department. Heather Holmes, Derek Mallia, and Kai Wilmot all worked together on the project, later co-founding Trace AQ with Victor Gill, who joined as the founding CEO to aid in commercialization efforts.

“Trace AQ exactly represents the kind of company we aim to launch,” Tom Georgis, with the U’s Energy Accelerator, shared, “they’ve transitioned their research into a startup that can make a difference in solving urgent problems.”

Wilmot noted that from the foundation of Trace AQ, the goal was to commercialize their technology, contributing to the University of Utah’s mission of use-inspired research and tech-based economic development.

He shared that commercialization “offers value in a way that we can build a company, and it offers value that’s less dollar signs based, but it’s more like, ‘let’s actually make something of this technology and keep it alive.’”

For scientists in academia, he emphasized that commercialization and tech-based development are good ways to keep projects continually growing, expanding, and actively helping people. Where academic projects might run out of funding and end as research papers on a shelf, commercialization offers opportunities for long-term growth and prolonged impact.

Finding a Balance Between Research and Business

Throughout the commercialization process, Wilmot, Holmes, and Mallia worked with the University of Utah’s Technology Licensing Office and the Venture Hub’s Energy Accelerator, which facilitates the launching of energy-related technology startups on campus. The Energy Accelerator helps startups to advance their technology, identify market opportunities, create business plans and commercialization strategies, and provide access to investment networks. As the co-founders of Trace AQ worked to commercialize their technology and find investors, they found a challenging barrier between their science experience and the realm of business and entrepreneurship.

“Initial investors were kind of leery of the fact that we didn’t have any meaningful business experience on board,” Wilmot shared about the process of finding investors, “It felt like we kept hearing, ‘yeah, I trust that your technology is good, but I don’t trust that you know what you’re doing from a business perspective.’ Which was a fair critique.”

The more the team at Trace AQ worked to find investors, the more they considered bringing in someone new to handle the business side of the company. It proved difficult, as academics with extensive scientific backgrounds, to navigate the world of investors and marketing strategies.

“The expertise and skill and effort of really putting that emphasis on the business side of things is a whole other job,” Wilmot said. “You either need to be willing to step away from your science and really put time and effort into learning those skills and being that person and championing the company in business lingo and a business perspective, or you need to find somebody to fill that role.”

Eventually, the team had to ask themselves where they wanted to spend their time, if they wanted to keep focusing on their science and technology or if one of them wanted to learn how to navigate the business side of commercialization. The choice was made when they brought in Victor Gill as the CEO, where he’s been driving commercialization efforts ever since.

Next Steps and Goals

After closing their $1.25 million seed round last year, Trace AQ’s next big goal is to deliver their forecasting capabilities to organizations and individuals that need it. Along with Flow AQ, the company recently released Trace AQ | Aero, a tool for scientists and researchers to improve air quality advisories. Those using the tool for the public good, like researchers, can apply for deep discounts. In addition to wildfire smoke forecasts, they will have accessible and accurate ozone and dust forecasts available to their users, making it easier to minimize exposure to hazardous air.

Learn more about Trace AQ.

Learn more about the University of Utah’s Venture Hub.  

Pile of old electronics

When single-use electronics are discarded, they often end up in U.S. landfills or are exported overseas for processing. EnduraCure, a University of Utah startup, is addressing this sustainability challenge by developing high-performance polymer substrates that can be chemically degraded to recover valuable electronic components. The company recently received the National Science Foundation's Phase 1 Small Business Technology Transfer (STTR) award, funding continued research and commercialization efforts.

A critical environmental issue

According to the Environmental Protection Agency, electronic waste is one of the fastest-growing environmental problems in the world, posing significant risks both to workers who handle these materials and to the environments where they're disposed.

These materials contain precious metals found in circuits that have inherent value for reuse, but current disposal processes often leave them in landfills. Toxic materials like lead, mercury, cadmium, and arsenic can leach into the environment and expose disposal workers to high levels of contaminants. In response, the NSF and related organizations have encouraged researchers to develop reusable and reclaimable solutions.

Lightening the load on landfills

EnduraCure is answering that call. Their technology uses a photocured polymerization process to create flexible substrates that match the durability of conventional materials during use but can be broken down in a mild chemical bath at end-of-life—recovering valuable components in the process.

“It's all about making these products degradable by design,” says EnduraCure CEO Dennis Pruzan. “We're pushing towards a circular economy and reducing loads on landfills.”

The company's initial focus is on flexible electronic substrates and encapsulants—materials used in medical sensors, smart packaging, and wearable devices. These applications demand both performance and flexibility, making them ideal candidates for EnduraCure's sustainable alternative to conventional nonrecyclable materials.

Freedom to innovate

The company originated in Dr. Chen Wang's lab in the Department of Materials Science and Engineering, where sustainable polymers are the central research focus. Pruzan completed his PhD in Materials Science at the U in 2018, then spent several years in industry working on carbon fiber products at DPS Skis. Wang recruited him back to the lab as a research associate, and when EnduraCure needed dedicated leadership, Pruzan's combination of academic training and industry experience made him a natural fit to take the lead.

“One of the things I admire most about the way Chen operates his lab is that it's with an eye on translational research,” Pruzan explains. “We don't want to do research for the sake of doing research. We want to do research that has economic value.”

In recent months, Pruzan and his team have shifted their work from the lab into a separate business and commercialization space, seeking both funding and collaborators as they establish themselves in this new environment.

A university-supported funding pipeline

To bridge the funding gap between academic research and commercialization, EnduraCure secured an Ascender Grant from the Technology Licensing Office— stopgap funding that proved critical while the team pursued the STTR.

“It was incredibly efficient,” Pruzan recalls. “We were notified of funding within a month. Relative to the NSF process, which is eight months to a year, it was very nice that it moved so quickly.”

Pruzan also participated in the NSF I-Corps program through the U of U, an intensive customer discovery process that reshaped how the team thought about their market. The team's successful pursuit of the NSF STTR Phase 1 Award provides funding to establish themselves as a company and move beyond the university research environment—an important milestone in their translational research journey.

Looking ahead

In coming months, the EnduraCure team plans to seek out a manufacturing partner—ideally an electronics company with whom they can demonstrate environmentally sustainable and cost-effective ways to degrade used devices and recover valuable materials at scale. Success would position the company for Phase 2 NSF funding.

“A big part of my job right now is making connections and getting to know people in the landscape of entrepreneurship and small businesses,” Pruzan says. “It's very clear that Utah has a wealth of resources to make those connections.”

Get involved

  • For U of U researchers: Interested in exploring commercialization for your own work? The Ascender Grant and I-Corps program help bridge the gap between lab discoveries and market applications.
  • For industry partners: EnduraCure is actively seeking manufacturing partners in flexible electronics, medical devices, and consumer electronics. Contact the Technology Licensing Office to learn more.

Upcoming Events

Tech Tuesday
04-07-2026 5:00 pm
Tech Tuesday
07-14-2026 5:00 pm

Full Calendar

 

Connect With Us

Subscribe to the Innovtion Report newsletter:

Join our list

follow us on social:

  LinkedIn    X    Instagram

Questions?

We support you and your innovation.

Wherever you are on your innovation journey, the Technology Licensing Office is your go-to source to connect you with the U’s innovation ecosystem.

Call 801.581.7792 or send us a message