This technology utilizes human umbilical cord mesenchymal stem cell sheets to promote uterine tissue regeneration and reduce fibrosis.

The challenges in treating uterine fibrosis and scarring post-surgery include complications in future pregnancies, low engraftment and survival of transplanted stem cells, and a dearth of effective regenerative treatments

The proposed method utilizes innovative temperature-responsive cell culture dishes to grow human umbilical cord mesenchymal stem cell (hUC-MSC) sheets, which are pivotal for regenerating uterine tissue and reducing fibrosis following surgical procedures like cesarean sections and myomectomies. This technique is particularly beneficial for enhancing post-surgical uterine healing and offers a new avenue for regenerative therapies in treating conditions such as Asherman’s syndrome. Furthermore, this approach represents a significant advancement in wound care and tissue engineering, with the potential to be applied to other tissues that necessitate regenerative treatments, thereby broadening the scope of its clinical applications.

Pre-Clinical Validation

• Preservation of cell-cell communication and extracellular matrix, facilitating natural cell functions post-transplantation.
• Enhanced paracrine effects due to the preservation of cytokine expression.
• Simplified and scalable production process adaptable to various clinical needs.
• Improved cell survival and integration compared to traditional cell suspension injections.
• Potential reduction in complications associated with uterine surgeries.

Kuramoto, Goro et al. “Human Mesenchymal Stem Cell Sheets Improve Uterine Incision Repair in a Rodent Hysterotomy Model.” American journal of perinatology vol. 39,11 (2022): 1212-1222. doi:10.1055/s-0040-1721718

CSTEC https://www.cstecutah.com/

Aaron Duffy
(801) 585-1377
aaron.duffy@utah.edu